While in potions class at Hogwarts he was showing off to Slughorn by making a permeant shrinking potion.
Unfortunately it worked as he spilt it on his nose and hair resulting in a loss of a nose and hair forever!!
~District_Gryffindor
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Why Voldemort Doesn't Have A Nose (Fandom Questions Series, Book1)
RandomFirst book of series! Many different reasons Voldemort may have lost his nose!!!