Kara had known pain. Pain when she watched Krypton explode, pain when she fought aliens and other people, pain when Reign defeated her, pain when she watched her former nemesis die for her, even pain when she had to send Mon el into space, but all of those combined didn't match up to the pain she was going through right now. They had finally done it they had broke the girl of steel, with the death of her last blood relative she was vulnerable. Even the Emerald Archer couldn't stop them this time. The heroes on Earth 1 also heard and they are not stopping until all the kryptonite is gone. When you mess with one of them, you mess with all of them. Especially when you mess with Kara Danvers.