1. Mia Talerico as Mackenzie Shepherd-Sloan
2. Ellen Pompeo as Dr. Meredith Grey
3. Sandra Oh as Dr. Cristina Yang
4. Katherine Heigl as Dr. Izzie Stevens
5. Justin Chambers as Dr. Alex Karev
6. T.R. Knight as Dr. George O'Malley
7. Chandra Wilson as Dr. Miranda Bailey
8. James Pickens Jr. as Dr. Richard Webber
9. Kate Walsh as Dr. Addison Montgomery
10. Sara Ramirez as Dr. Callie Torres
11. Isaiah Washington as Dr. Preston Burke *
12. Patrick Dempsey as Dr. Derek Shepherd
13. Eric Dane as Dr. Mark Sloan
14. Brooke Smith as Dr. Erica Hahn
15. Chyler Leigh as Lexie Grey
16. Kate Burton as Dr. Ellis Grey *
17. Chris O'Donnell as Dr. Finn Dandridge *
18. Jeffrey Dean Morgan as Denny Duquette Jr.
19. Kyle Chandler as Dylan Young
20. Héctor Elizondo as Carlos Torres
21. Kali Rocha as Dr. Sydney Heron
22. Monica Keena as Bonnie Crasnoff
23. Anna Maria Horsford as Elizabeth Fallon
24. Elizabeth Reaser as Ava/Rebecca Pope
25. Loretta Devine as Adele Webber
26. Sarah Utterback as Nurse Olivia Harper
27. Jeff Perry as Thatcher Grey
28. Embeth Davidtz as Nancy Shepherd
29. Debra Monk as Louise O'Malley
30. Amy Brenneman as Dr. Violet Turner +
31. Paul Adelstein as Dr. Cooper Freedman +
32. Tim Daly as Dr. Pete Wilder +
33. Chris Lowell as Dell Parker +
34. Taye Diggs as Dr. Sam Bennett +
35. Merrin Dungey as Dr. Naomi Bennett +
/ / /
256 words
Published: 11/19/2021
* - Character's last appearance
+ - Private Practice characters
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