The South Park boys have gone their separate ways after attending South Park University. Luckily, Craig and Kenny were lucky enough to share a dorm room and become the closest of friends. Months pass and Kenny hears about Cartman dating his younger sister who is still in high school. Kenny gets all the boys together to help him get to the root of this. All the time spent together reunites their friendship and leaves Craig out of the circle. Craig feels abandoned, which leads to a moment that would change their lives forever.