The Cordyceps Brain Infection is a deadly disease, which is the death sentence of everyone who is infected. But not Ellie. Ellie is immune, which made her the key and only hope for a vaccine or remedy. Four years ago Joel decided to choose Ellie's life over the life of every living human being by killing almost every member of the organization and the doctor's who were willing to sacrifice Ellie for a higher cause. Ellie never forgave Joel for deciding over her life, but when a former member of the organization arrives at their hometown, Joel gets the chance to make up for what he did.