Avery Lockwood and Negomi Falkon are two assassins from the tenth century. Having fled Greece, they wound up in Masyaf, Syria. But this isn't their final voyage. Their story takes them through hundreds of years, from Greece to New York, going through places like Italy, France and Boston USA. Along the way they meet more of their order, and befriend them. But in the year 2012, with a freak Animus accident, the Assassin's they met and effected are pulled into their future, and everything goes sideways