*Not listed in any specific order
1. Helen Lovejoy
- Even though she's one of the religious characters (she's married to the revernard) I believe she will still cheat on her spouse.
2. Shauna Chalmers
- She literally cheated on her age appropriate boyfriend with a 10 year-old
- She cheated on Jimbo with multiple guys she even made out with an older dude (Gil)
- She needs help3. Kearney
- Even though he doesn't pull he will still cheat on his lover/partner if he had a chance to do so
4. Jessica Lovejoy
- Like mother like daughter, she's a cheater
- She only dates guys to get what she wants
- She would leave her current boyfriend for another guy she likes if she is in a good mood but would still cheat on you nevertheless5. Mayor Quimby
- It's kinda obvious