XX years after the events of Hopes Peaks' killing game, orchastrated by the Ultimate Fashonista and Ultimate Despair, Junko Enoshima. Junko's influence had unjowingly spread to other countries, one example is the country of the Unites States of America. 16 Talented People, all ranging in age, all trapped in the school where every talented person comes to hone their skills, the school of XXXX. All forced to participate in a killing game that will or will not end their lives.