The Ohana Gang is back! After a year of capturing Hamsterviel and the Leroys, everyone are now living in peace. But then, Leroy and Hamsterviel escape back to Earth to destroy it and the experiments as well. With a little help from Jumba, Pleakly, Gantu, Rueben, and their ohana, Lilo and Stitch are determined and more stronger than ever to put Hamsterviel and Leroy back to prison, but not without a little choas, problems and a new experiment along the way.