CIP

CIP ( Congenital insensitivity to pain )

Congenital insensitivity to pain is a condition that inhibits the ability to perceive physical pain. From birth, affected individuals never feel pain in any part of their body when injured.
People with this condition can feel the difference between sharp and dull and hot and cold, but cannot sense.

For Example,  when they are touching a hot thing or a cold thing Also They can't distinguish it .
So they can't understand How dangerous is that .
CIP is considered a form of peripheral neuropathy because it affects the peripheral nervous system, which connects the brain and spinal cord to muscles and to cells that detect sensations such as touch, smell, and pain.

Frequency: CIP is the rare condition about 20 cases have been reported in the scientific literature.

Causes : there is mutations SCNPA gene cause CIP a part of sodium channel and transfer sodium atoms into cells and play a key role in a cell's ability to generate and transmit electrical signals. Sodium called NaV.17 .

inherited :
The condition is inhereited in an autosomal recessive pattern, which means both copies of the gene in each cell have mutations. The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they typically do not show signs and symptoms of the condition.

treatment:
Giving naloxone (an opioid antagonist) helped a woman feel pain for the first time. Similar effects were observed in mice (with Nav1.7 inactivated) when treated with naloxone. Therefore, opioid antagonists such as naloxone and naltrexone may be effective in treating the condition.

Other name of this condition:
* Asymbolia for pain
* Channelopathy-associated insensitivity to pain

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Reference:
* Dabby R. Pain disorders and erythromelalgia caused by voltage-gated sodium channel mutations. Curr Neurol Neurosci Rep. 2012 Feb;12(1):76-83. doi: 10.1007/s11910-011-0233-8. Review

Written by SOOM