Oscorp Industries, a rising economic power in New York City, wages a covert war against S.H.I.E.L.D. as it struggles to recover from H.Y.D.R.A.'s violent coup. Acting on behalf of Norman Osborn, Janet Carlisle seeks to uncover a scandal capable of bringing down Director Mace and his Inhuman agents, despite the fact that she herself has recently acquired a dangerous array of mystical powers. Cassie Powell, a young woman who came to Kamar-Taj seeking answers, has taken up residence in the Sanctum Sanctorum with her new mentor, Doctor Strange. Plagued by destructive abilities that she cannot control, she hopes to find a way to live without the fears that torment her. When a series of unfortunate events and unusual circumstances cause Janet to arrive on the doorstep of the Sanctum, Strange finds himself face to face with his past love, and Cassie discovers a threat that surpasses any she has yet encountered.