Derek: "Isaac, I know you believe I can take this tumor out, and I wish I could. But this surgery will kill you."

Isaac: "Take the scans. Look them over. But stop your mind before the part where it gets to "no." Think "yes." Yes?"

Cristina: "Shepherd, I've been paging you. Shunt patient, OR two" she looks up at the scans and moves closer to them "Screw the shunt. Let's operate on that."

Mark: "You know what this is about, right?" he asks pacing a little behind Derek as he looks at the scans 

Derek: "Mnh-mnh."

Mark: "You're no longer daddy's favorite, so you've gone in search of some crazy ass tumor to get his love back."

Derek: "Actually, it's about my patient. I haven't made up my mind yet. I'm just looking."

Callie: "Isaac has a cord tumor?" she asks coming into the room

Cristina: "Oh, it's awesome. Look."

Callie: "Awesome in a bad way. It's eaten five levels of his spine. Wait, you're not seriously considering trying to take it out?"

Cristina: "Of course he is. He's Shepherd."

Arizona: "It's a bad case of telophone, right? Isaac's got a bone spur or a herniated disk, not a..." Callie holds up the scans for her to see "He diagnosed an osteosarcoma case for me a month ago. I thought it was a shadow, but it turned out to be the tiniest little lesion on an x-ray."

Mark: "That says more about you than it does him."

Arizona: "I'm sorry. Do you even know who Isaac is?"

Mark: "No idea."

Lexie: "Hey, what's everyone...oh, a spinal tumor. I read about a case at Mayo where the surgery took 17 hours. The head surgeon had four rotating assistants, one of whom just administered fluids."

Cristina: "Okay, you know what? Don't try and Lexopedia your way on this. This is my tumor."

Arizona: "What happened to the patient at Mayo?"

Lexie: "He died. That's why it only took 17 hours."

Owen: "Hey, I just heard. Isaac has an inoperable tumor?"

Lexie: "It's Isaac's tumor?"

Cristina: "Okay, yeah, yeah. Boo-hoo, okay? Who says it's inoperable?"

Derek: "Cristina." he motions to the screens as a visual of the tumor comes up

Callie: "Oh, come on. It's all the way up to t-2."

Mark: "See, this is why I got into plastics."

Arizona: "Oh, that's gotta be..." they all start talking over each other when Richard walks past the room and comes inside

Richard: "Why aren't you all at your surgeries? Go, get to your ORs. Don't screw with my schedule on day one." he says as everybody but Derek walks out the room

Sky: "Everyone said you'd found the great white of tumors, but just had to see it for myself." Derek comes into the room where Sky is looking at the scans

Derek: "And now that you have?"

Sky: "You want my fellow attending answer or my fellow surgeon answer?" she smiles at him 

Derek: "Fellow surgeon."

Sky: "This tumor is dangerous...complicated...and smart...beautiful. This is like the holy grail of tumors. To successfully take out this tumor would be an achievement you could hang your hat on for the rest of your career. You could retire on this tumor." she says as he smiles at her a little

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