"Come on, Spidey. What's wrong with teaming up with your best buddy, Deadpool?"
"Louis, you just tried to shoot me the other day."
"Well you lived, didn't you?"
In an effort to seek protection from an unknown enemy, Deadpool teams up with Spiderman and they both get more than the bargained for with this whole 'superhero' thing.
Spiderman!Harry + Deadpool!Louis