(Side note; yes, I am discluding quite a few characters. So what? Also, I am choosing these not by everything online, but by actual personality, because it's bullshit that Gemini and Sagittarius aren't batman and joker. Seriously. It's bs, they act exactly like them. I have enough reasoning.)
Harley Quinn: Sagittarius, Aquarius,
Harley Q is a mix of Mikey and Raph, she would rather not think things through. At least, not any more. She is wild and wacky, and an overall fun character.
Joker: Gemini, Libra
Joker is a mix of Raph and Leo, he takes leadership when necessary and loves to see the suffering of others. The Joker loves to laugh, and is a powerful man. He might seem hilarious and amazing at first, but when you dig deeper, it's not hard to see that with one swift action he can ruin your life. (COUGH COUGH GEMINI MOST LIKELY HAS SCREENSHOTS TO RUIN YOUR LIFE COUGH)
Enchantress: Capricorn, Scorpio, Virgo
Enchantress is full blown Raph. She doesn't take orders from anybody and will murder anything in her way.
Batman: Aries, Leo, Taurus
Come on, who doesn't know batman? Batman is most like Leonardo, due to his urge to help others and take leadership. Although, not Donnie, because without super computer to tell him what's what, he probably wouldn't know how to use Have of his tech :p
N/A: Cancer, Pisces