While seeking origins others have suggested examination of some similarities to the Babylonian creature, Humbaba, in the Gilgamesh epic.

A number of early classics scholars interpreted the myth of the Medusa as a quasi-historical, or "sublimated" memory of an actual invasion.

The legend of Perseus beheading Medusa means, specifically, that 'the Hellenes overran the goddess's chief shrines' and 'stripped her priestesses of their Gorgon masks,' the latter being apotropaic faces worn to frighten away the profane.

That is to say, there occurred in the early thirteenth century B.C. an actual historic rupture, a sort of sociological trauma, which has been registered in this myth, much as what Freud terms the latent content of a neurosis is registered in the manifest content of a dream: registered yet hidden, registered in the unconscious yet unknown or misconstrued by the conscious mind

Transitions in religious traditions over such long periods of time may make some strange turns. Gorgons are often depicted as having wings, brazen claws, the tusks of boars, and scaly skin. The oldest oracles were said to be protected by serpents and a Gorgon image was often associated with those temples. Lionesses or sphinxes are frequently associated with the Gorgon as well. The powerful image of the Gorgon was adopted for the classical images and myths of Athena and Zeus, perhaps being worn in continuation of a more ancient religious imagery. In late myths, the Gorgons were said to be the daughters of sea deities, Ceto the sea monster and Phorcys (her brother-husband).

Homer, the author of the oldest known work of European literature, speaks only of one Gorgon, whose head is represented in the Iliad as fixed in the centre of the aegis of Athena:

About her shoulders she flung the tasselled aegis, fraught with terror ... and therein is the head of the dread monster, the Gorgon, dread and awful...

Its earthly counterpart is a device on the shield of Agamemnon:

...and therein was set as a crown the Gorgon, grim of aspect, glaring terribly, and about her were Terror and Rout.

The date of Homer was controversial in antiquity, and is no less so today. Herodotus said that Homer lived 400 years before his own day, which would place Homer about 850 BC; but other ancient sources gave dates much closer to the Trojan War.  Those who believe that the stories of the Trojan War derive from a specific historical conflict usually date it to the twelfth or eleventh centuries BC, often preferring the dates given by Eratosthenes, 1194-1184 BC, which roughly correspond with archaeological evidence of a catastrophic burning of Troy VIIa.

For modern scholarship, 'the date of Homer' refers to the date of the poems as much as to the lifetime of an individual. The scholarly consensus is, that "the Iliad and the Odyssey date from the extreme end of the ninth century BC or from the eighth, the Iliad being anterior to the Odyssey, perhaps by some decades."  They are presumed to have existed previously as an oral tradition that eventually became set in historical records. Even at that early time the Gorgon is displayed as a vestige of ancient powers that preceded the historical transition to the beliefs of the Classical Greeks, displayed on the chest of Athene and Zeus.

In the Odyssey, the Gorgon is a monster of the underworld into which the earliest Greek deities were cast:

...and pale fear seized me, lest august Persephone might send forth upon me from out of the house of Hades the head of the Gorgon, that awful monster...

Around 700 BC, Hesiod (Theogony, Shield of Heracles) imagines the Gorgons as sea daemons and increases the number of them to three - Stheno (the mighty), Euryale (the far-springer, or of the wide sea), and Medusa (the queen), and makes them the daughters of the sea deities Keto and Phorcys. Their home is on the farthest side of the western ocean; according to later authorities, in Libya. Ancient Libya is identified as a possible source of the deity, Neith, who also was a creation deity in Ancient Egypt and, when the Greeks occupied Egypt, they said that Neith was called Athene in Greece.

The Attic tradition, reproduced in Euripides (Ion), regarded the Gorgon as a monster, produced by Gaia to aid her children, the Titans, against the new Olympian deities. Classical interpretations suggest that Gorgon was slain by Athena, who wore her skin thereafter.

Of the three Gorgons of classical Greek mythology, only Medusa is mortal.

The Bibliotheca (2.2.6, 2.4.1, 2.4.2) provides a good summary of the Gorgon myth. Much later stories claim that each of three Gorgon sisters, Stheno, Euryale, and Medusa, had snakes for hair, and that they had the power to turn anyone who looked at them to stone. According to Metamorphoses, a Roman poet writing in 8 AD, who was noted for accuracy regarding the Greek myths, Medusa alone had serpents in her hair, and he explained that this was due to Athena (Roman version Minerva) cursing her. Medusa had sex with Poseidon (Roman version Neptune) in a temple of Athena after he was aroused by the golden color of Medusa's hair. Athena therefore changed the enticing golden locks into serpents. Diodorus and Palaephatus mention that the Gorgons lived in the Gorgades, islands in the Aethiopian Sea. The main island was called Cerna and, according to Henry T. Riley, these islands may correspond to Cape Verde. According to Pseudo-Hyginus the "Gorgo Aix", daughter of Helios, was killed by Zeus during the Titanomachy. From her skin, a goat-like hide rimmed with serpents, he made his famous aegis, and placed her fearsome visage upon it. This he gave to Athena. Then Aix became the goat Capra (Greek: Aix), on the left shoulder of the constellation Auriga. A primeval Gorgon was sometimes said to be the father of Medusa and her sister Gorgons by the sea Goddess Ceto. This figure may have been the same as Gorgo Aix as the primal Gorgon was of an indeterminable gender.

In the Aeneid, it is mentioned that the Gorgons lived in the entrance of the Underworld.

Pausanias (5.10.4, 8.47.5, many other places), a geographer of the second century AD, supplies the details of where and how the Gorgons were represented in Greek art and architecture.

In late myths, Medusa was the only one of the three Gorgons who was not immortal. King Polydectes sent Perseus to kill Medusa in hopes of getting him out of the way, while he pursued Perseus's mother, Danae. Some of these myths relate that Perseus was armed with a scythe from Hermes (Roman equivalent Mercury) and a mirror (or a shield) from Athena. Perseus could safely cut off Medusa's head without turning to stone by looking only at her reflection in the shield. From the blood that spurted from her neck and falling into the sea, sprang Pegasus and Chrysaor, her sons by Poseidon. Other sources say that each drop of blood became a snake. Perseus is said by some to have given the head, which retained the power of turning into stone all who looked upon it, to Athena. She then placed it on the mirrored shield called Aegis and she gave it to Zeus. Another source says that Perseus buried the head in the marketplace of Argos.

According to other accounts, either he or Athena used the head to turn Atlas into stone, transforming him into the Atlas Mountains that held up both heaven and earth.He also used the Gorgon against a competing suitor. Ultimately, he used her against King Polydectes. When Perseus returned to the court of the king, Polydectes asked if he had the head of Medusa. Perseus replied "here it is" and held it aloft, turning the whole court to stone.

In Ancient Greece a Gorgoneion (a stone head, engraving, or drawing of a Gorgon face, often with snakes protruding wildly and the tongue sticking out between her fangs) frequently was used as an apotropaic symbol  and placed on doors, walls, floors, coins, shields, breastplates, and tombstones in the hopes of warding off evil. In this regard Gorgoneia are similar to the sometimes grotesque faces on Chinese soldiers' shields, also used generally as an amulet, a protection against the evil eye. Likewise, in Hindu mythology, Kali is often shown with a protruding tongue and snakes around her head.

In some Greek myths, blood taken from the right side of a Gorgon could bring the dead back to life, yet blood taken from the left side was an instantly fatal poison. Athena gave a vial of the healing blood to Asclepius, which ultimately brought about his demise.

Heracles is said to have obtained a lock of Medusa's hair (which possessed the same powers as the head) from Athena and to have given it to Sterope, the daughter of Cepheus, as a protection for the town of Tegea against attack. According to the later idea of Medusa as a beautiful maiden, whose hair had been changed into snakes by Athena, the head was represented in works of art with a wonderfully handsome face, wrapped in the calm repose of death.

(In my opinion Medusa is the prettier sister out of all of them, a lot of the really important stuff came from Wikipedia I may know a lot about Mythology but I don't know everything.)

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