Because once is never enough.
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Two years after the first series of murders, as Sidney acclimates to college life and Katherine is getting herself back together, someone donning the Ghostface costume begins a new string of killings.
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Sidney is trying to get over the events of the Woodsboro massacre and is attending Windsor College with her surviving friend from high school, Randy, her new friends, Hallie and Mickey, as well as her new boyfriend, Derek.
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Kat has been in Westin Hills since the massacre that took not only the lives of her best friends but proved them both to be the Killers themselves, but now Kat is getting out of the psychiatric facility and is ready to take on her demons.
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What will happen when the twins see each other for the first time in over a year? Will the resentment and hostility between them be too much to redeem their bond, or will they come together in their time of need?