The Disease Susceptibility Genetic Test-APOE

The main function of the is to direct the synthesis of apolipoprotein E (APOE). The main precise healthcare solutions function of APOE is to participate in the transformation and metabolism of lipoproteins, participate in the regulation of lipid metabolism in the body, and is an important internal factor affecting the level of blood lipids in the body, considered to be an important susceptibility gene for hyperlipoproteinemia and atherosclerotic vascular disease.

Due to the polymorphism of the APOE genotype, the APOE protein is also polymorphic, with three different protein isoforms: APOE4, APOE3, APOE2. Some people have only one major isomer, that is, homozygotes; some people can have two major isomers, that is, heterozygotes. It can be seen that there are six different phenotypes in the population.

Features of the Disease Susceptibility Genetic Test-APOE

Among lipid-lowering drugs, statins are the most important lipid-lowering drugs, and more than 60% of patients will use statins to control blood lipids. Statins are hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitors and are widely used for the prevention and treatment of cardiovascular disease because of their cholesterol-lowering properties. Most patients with coronary heart disease may need to take statins for life.

Studies have reported that statins have the best lipid-lowering effect on APOE 2 carriers, but less effective on APOE 4 carriers. Detection of APOE gene before taking statins can scientifically evaluate the effect of individual medication and help patients who take medication to choose drugs.

Applicable Population of the Disease Susceptibility Genetic Test-APOE

1. People with bad eating habits, such as: like eating high-fat, high-calorie, pickled, smoked, fried foods.

2. People who smoke, who have been exposed to secondhand smoke for a long time, and who drink excessively.

3. People with irregular life and rest, long-term insomnia or staying up late, and lack of exercise.

4. People with long-term mental stress, anxiety, tension, irritability.

5. Overweight, obese people.

6. People with family history of cardiovascular and cerebrovascular diseases.

7. People with dyslipidemia.

Test of the Disease Susceptibility Genetic Test-APOE

The test is based on biochip technology. By detecting two gene loci that determine APOE protein polymorphism, it evaluates its impact on the risk of cardiovascular and cerebrovascular diseases, metabolic diseases, etc., and guides the subjects to carry out effective prevention and treatment, including adjusting diet, improving lifestyle, appropriate use of drugs, strengthening physical examination, etc.

Test Content:

Apolipoprotein E-Related Disorders [10 items]

Hypertension, coronary heart disease, ischemic stroke (cerebral infarction), atherosclerosis, deep vein thrombosis, Alzheimer's disease, Parkinson's disease, type 2 diabetes, diabetic nephropathy, age-related macular degeneration

Lipid-lowering drug sensitivity [7 items]

Probucol, Fenofibrate, Atorvastatin, Simvastatin, Pravastatin, Fluvastatin, Rosuvastatin

Blood lipid related indicators [5 items]

Apolipoprotein E, LDL cholesterol, HDL cholesterol, triglycerides, total cholesterol

The effect of diet on blood lipids [3 items]

Unsaturated Fat, Cholesterol, Digestible Carbohydrates

Specification of the Disease Susceptibility Genetic Test-APOE

Sample types

Venous blood / Oral swab

TAT

9 working days

Technology Co, Ltd. is the industrialized platform of CapitalBio Corporation and Biochip Beijing National Engineering Research Center and one of the core enterprises of Tsinghua University in the field of life and health. CapitalBio Technology was registered and established in August 2012 and had production, R&D bases and marketing operation centers for biochips, instrument and equipment in Beijing, Shanghai, Chongqing, Chengdu, Dongguan, Hong Kong (China) and San Diego and other places, with a total office area of over 150,000 ㎡ and employees of over 2,000 persons.

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