Scott McCall - Stiles, Lydia and Derek
Sam Winchester - Castiel, Dean, Crowley and Gabriel
Barry Allen - Caitlyn and Cisco
Prince Ben - Eve, Carlos and Jay
Sebastian Smythe - Blaine and Kurt
Peter Parker - Wanda, Steve, Natasha and Pietro (before he died :( )
Johnny Storm - Susan
Kendall Knight - Carlos, Logan and James
Stefan Salvatore - Bonnie, your siblings, Damon and Kai
Steve Rogers - Loki, Sam, T'Challa and Scott
Klaus Mikaelson - Gabriel, Castiel, his siblings and Crowley.
Prince Francis - Sebastian and Claude
Derek Hale - Scott and Stiles
Bruce Wayne - You don't really have any best friend. You propaly would call Bruce your best friend.