Karen Gillian as Dr. Tara Parks
Patrick Dempsey as Dr. Derek Shepherd
Ellen Pompeo as Dr. Meredith Grey
Sandra Oh as Dr. Cristina Yang
Sebastian Stan as Dr. Timothy Stone
Katherine Heigl as Dr. Izzie Stevens
Justin Chambers as Dr. Alex Karev
T.R. Knight as Dr. George O'Malley
Chandra Wilson as Dr. Miranda Bailey
James Pickens, Jr. as Dr. Richard Webber
Isaiah Washington as Dr. Preston Burke