Norman Osborn/The Green Goblin- Liev Schreiber
Otto Octavius/Doctor Octopus- Jeffrey Wright
Max Dillion/Electro- Anthony Ramos
Flint Marco/The Sandman- Sam Worthington
Aleksei Mikhailovich Sytsevich/The Rhino- Florian Munteanu
Quentin Beck/Mysterio- Zachary Quinto
Curt Connors/The Lizard- Damian Lewis