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63. The 5 Hazards of Human Spaceflight:

1. Radiation
The first hazard of a human mission to Mars is the most difficult to visualize because it's invisible to the human eye. Above Earth's natural protection, radiation exposure increases cancer risk, damages the central nervous system, can alter cognitive function, reduce motor function, and prompt behavioural changes.
The space station sits just within Earth's protective magnetic field, so while our astronauts are exposed to ten-times higher radiation than on Earth, it's still a smaller dose than what deep space has in store.

2. Isolation and confinement
Behavioural issues among groups of people crammed in a small space over a long period of time, no matter how well trained they are, are inevitable. Crews will be carefully chosen, trained and supported to ensure they can work effectively as a team for months or years in space.
On a trip to Mars, astronauts will be more isolated and confined than we can imagine. Sleep loss, circadian desynchronization (a disorder of the body clock), and work overload create an issue and may lead to performance decrements, adverse health outcomes, and compromised mission objectives.

3. Distance from Earth
The third and perhaps most apparent hazard is, quite simply, the distance. Mars is, on average, 140 million miles from Earth. Rather than a three-day lunar trip, astronauts would be leaving our planet for roughly three years. While International Space Station expeditions serve as a rough foundation for the expected impact on planning logistics for such a trip, the data isn't always comparable.
If a medical event or emergency happens on the station, the crew can return home within hours. Additionally, cargo vehicles continual resupply the crews with fresh food, medical equipment, and other resources. Once you burn your engines for Mars, there is no turning back and no resupply.

4. Gravity (or lack thereof)
The variance of gravity that astronauts will encounter is the fourth hazard of a human mission. On Mars, astronauts would need to live and work in three-eighths of Earth's gravitational pull for up to two years. Additionally, on the six-month trek between the planets, explorers will experience total weightlessness.
Besides Mars and deep space, there is a third gravity field that must be considered. When astronauts finally return home they will need to readapt many of the systems in their bodies to Earth's gravity. Bones, muscles, cardiovascular system have all been impacted by years without standard gravity. To further complicate the problem, when astronauts transition from one gravity field to another, it's usually quite an intense experience. Blasting off from the surface of a planet or a hurdling descent through an atmosphere is many times the force of gravity.

5. Hostile/closed environments
A spacecraft is not only a home - it's also a machine. The ecosystem inside a vehicle plays a big role in everyday astronaut life. Important habitability factors include temperature, pressure, lighting, noise, and quantity of space. It's essential that astronauts are getting the requisite food, sleep and exercise needed to stay healthy and happy.
Technology, as often is the case with out-of-this-world exploration, comes to the rescue in creating a habitable home in a harsh environment. Everything is monitored, from air quality to possible microbial inhabitants. Microorganisms that naturally live on your body are transferred more easily from one person to another in a closed environment.
Astronauts, too, contribute data points via urine and blood samples and can reveal valuable information about possible stressors. The occupants are also asked to provide feedback about their living environment, including physical impressions and sensations so that the evolution of spacecraft can continue addressing the needs of humans in space. Extensive recycling of resources we take for granted is also imperative: oxygen, water, carbon dioxide, even our waste.

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