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24hormom.LH,ACTH,TSH

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Cau 24: cac hormon: GH, ACTH, TSH : ban chat, tac dung, dieu hoa bai tiet va UDLS

a) hormon phat trien co the GH (hGH)

*) ban chat hoa hoc: GH la 1 ptu pr chua 191 acid amin trong moi chuoi don va co trong lg ptu la 22005 dvc.

*) tac dung: GH lam phat trien tat ca cac mo co knang tang truong trong co the. No vua lam tang kick thuoc Tb vua lam tang tang qtrinh phan chia TB do do lam tang trong lg co the, lam tang kick thuoc cac phu tang.

- kick thick mo sun va xuong phat trien:

+) tang lang dong pr o cac TB sun va TB tao xuong

+) tang toc do sinh san cac TB sun va te bao tao xuong

+) tang chuyen cac TB tao sun thanh cac TB tao xuong

- kick thick sinh tong hop pr :

+) tang vc acid amin qua mang TB

+) tang qtrinh sao chep ADN cua nhan TB de tao ARN

+) tang qtrinh dich m• ARN de lam tang tong hop pr tu ribosom

+) giam qtrinh thoai hoa pr va acid amin

- tang tao nang lg tu nguon lipid:

+) tang giai phong acid beo tu cac mo du tru, do do lam tang Cm acid beo trong mau.

+) chinh vi td nay ma ng ta coi td huy dong lipid cua GH la 1 trong nhung td qtrong nhat nham tiet kiem pr de dung no cho su phat trien co the

- tac dung len chuyen hoa glucid:

+) giam glucose cho muc dich sinh nang lg

+) tang du tru glycogen o TB

+) giam vc glucose vao TB va tang Cm glucose trong mau

+) tang bai tiet insulin: Cm cua glucose trong mau tang duoi td cua GH d• kick thick tuyen tuy noi tiet bai tiep insulin, dong thoi chinh GH cung co tac dung kick thick truc tiep TB beta cua tuyen tuy

*) dieu hoa bai tiet:

- vung duoi doi: GH dc bai tiet duoi su dkhien gan nhu hoan toan cau hai hormon vung duoi doi la GHRH va GHIH

- Somatostatin la 1 hormon tai cho do nhieu vung n•o va dg tieu hoa bai tiet cung co td uc che bai tiet GH

- Cm glucose giam trong mau, Cm acid beo trong mau giam, thieu pr nang va keo dai se lam tang bai tiet GH

- Tinh trang stress, chan thuong, luyen tap gang suc se lam tang bai tiet GH

- o ng vn, Cm GH trong mau cuong ron tre so sinh la 28,38 +- 10,03 ng/ml, ng truong thanh la 3,94 +- 2,09 ng/ml

b) hormon kick thick tuyen giap: TSH

*) ban chat hoa hoc: TSH la 1 glycoprotein, co trong lg ptu 28000

*) tac dung:

- tac dung len ctruc tuyen giap:

+) tang so lg va kick thuoc TB tuyen giap trong moi nang giap

+) tang bien doi cac TB nang giap tu dang khoi sang dang tru( dang bai tiet)

+) tang he thong phat trien mao mach cau tuyen giap

- tac dung len cnang tuyen giap

+ tang hd bom ion do do lam tang knang bat ion cua TB tuyen giap.

+ tang gan iot vao tyrosin de tao hormon tuyen giap

+ tang phan giaI thyroglobulin dc du tru trong long nang de giaI phong hormon tuyen giap vao mau va do do lam giam chat keo trong long nang tuyen.

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