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Etoricoxib is the newset of the COX-II inhibitors released onto the market by Merck Frosst. Etoricoxib can be used to treat acute gouty arthritis, osteoarthirtis and other conditions as determined by your doctor. Etoricoxib is administered orally and may be taken with or without food. The onset of Etoricoxib effect may be faster when Etoricoxib is administered without food. This should be considered when rapid symptomatic relief is needed. Osteoarthritis: The recommended dose of Etoricoxib is 60 mg once daily. Rheumatoid arthritis- The recommended dose is 90 mg once daily. Acute gouty arthritis- The recommended dose of Etoricoxib is 120 mg once daily. ETORICOXIB 20 mg should be used only for the acute symptomatic period. In clinical trials for acute gouty arthritis, Etoricoxib was given for 8 days. Doses greater than those recommended for each indication have either not demonstrated additional efficacy or have not been studied. Therefore, the dose for each indication is the maximum recommended dose. ETORICOXIB is contra-indicated in: - patients with known hypersensitivity to etoricoxib or to any of the excipients of this medicinal product - patients with active peptic ulceration or gastro-intestinal (GI) bleeding - patients with severe hepatic dysfunction (Child-Pugh score>9) - patients with estimated creatinine clearance <30 ml/min - patients who have developed signs of asthma, acute rhinitis, nasal polyps, angioneurotic oedema or urticaria following the administration of acetylsalicylic acid or other non-steroidal anti-inflammatory drugs (NSAIDs) - pregnancy and lactation (see 4.6 'Pregnancy and lactation' and 5.3 'Preclinical safety data') - children and adolescents under 16 years of age - patients with inflammatory bowel disease - patients with severe congestive heart failure.













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