My Destiny is the story of Grace Dela Rosa, a woman who's willing to sacrifice everything, even her romantic aspiration, for her family. Grace decided to work abroad and walk away from her own family to give way to her sister's happiness. Saddened by Grace's decision to work abroad, Matthew continues his medical studies. Matthew then meets Joy at medical school.
Joy is the younger sister of Grace who suffers from leukemia. She's losing her will to live until she meets Matthew. Will Joy's illness lead her to fulfilling her heart's desires?