Shiomaki lost her mother to the government of her region because she used Alchemy which was thought if "witchery". She would get her back no matter what so she sets off in search of her friend Alphonse who is said to know Alchemy and thinks he can teach her. But in search for him she sort of teaches herself. When she finally gets to their village Resembool. She tries to pull of the forbidden taboo. Human Transmutation. A friend helps her back to health but she can no longer see. She has to cope with blindness and being an alchemist all at the same time facing troubles with Dream Catchers and later on Homunculi.