Samantha Karev. She and her three other siblings, Alex, Aaron and Amber have had a tough childhood. With their mom becoming mentally ill, and their dad becoming a dead beat, their older brother Alex Karev had to take care of them. Being in and out of foster homes isn't a good life to have. When Samantha finally reached the age of 18 she left for college to become a surgeon just like her older brother. Years have passed. She was on her second to last year of residency at the local hospital in California where she lived with her current boyfriend William. What Samantha didn't know is that William had a past of violence. She quickly figured out when he started hitting her. He beats her again. After hitting him with a glass plate, she leaves him, driving to Seattle to see her brother, but ends up in a car accident. What will happen when she see's her brother for the first time in two years? Will a new relationship develop between her and a current resident?