Sixteen year old Serena Yovonne has finally achieved her dream of becoming Kalos Queen but when Ash finally wins the Kalos league things begin to change. While Ash wants to Serena to come with him to the Cordellica region so he can challenge the battle brigade; which is the final step for him to become a Pokemon master; Serena wants to stay in Kalos and keep up with the busy schedules and demands that come with being Kalos Queen. Ash and Serena get into a huge fight. Ash looses his temper and tells Serena that he hates her. Serena runs into the woods so she can think but she runs into Team Flare's leader Lysandre and he's after Serena. In an attempt to runaway Serena trips down the stairs and hits her head on on the steps and it causes amnesia. Ash tries to help Serena get her memories back while trying to figure out what Team Flare wants with her.