Cotton Candy Crossover (Despicable Me/Naruto)
Margo, Edith and Agnes accidently open up a portal and find themselves in the world of Naruto.
Disclaimer - I don't own Despicable Me or Naruto. This is written for Sci-Friday's hi-tech challenge, which is supposed to be seven parts. As such I don't yet know where the next chapters will go, but I'm going to tie it in somehow.
Note - For some reason the first thing that popped into my head for the prompt "villain's weapon" was Gru's Freeze Ray. While it is true he's a reformed villain, he was still a villain when he first used the tool, and he was trying for world domination.