Wendy House, the much younger, albeit equally as talented and sarcastic sister of famed Diagnostician Gregory House, has a secret. A very poorly-kept secret that her brother teases her about any chance he gets. She's also pretty different. She works as a Psychologist at Princeton Plainsboro Teaching Hospital, but she doesn't look or act like your average 'white coat'. Like her brother, she's sometimes neurotic, not to be restrained by rules or regulations, but there's one huge difference between Greg and Wendy; She deeply cares about the health and comfort of her patients. She has more than one friend. She's happy. At least, she tries to be. She has to pretend like it doesn't kill her when the man she has loved since she was 18 years old falls into yet another marriage that fails within two years. Can she find out how to deal with this problem and get over him? How long can she keep her feelings hidden? If they do end up together, will everything work out? Or will the one person they have in common in their lives, Greg House, somehow ruin everything, without even meaning to?