A school in Evanston, Illinois is ruled by a clique of 4 girls called "The Plastics". Another school in Sherwood, Ohio is ruled by 3 girls who share the same name: The Heathers. What do they have in common? They are the wealthiest, prettiest, and most popular girls in their respective schools, and are both headed by a queen bee who will stop at nothing to humiliate those beneath her. However, there can only be one alpha, so what happens when these two cliques study at the same school for a year?