Light in the Darkness
When Harry and Ron stop talking to Hermione during third year, she turns to her studies to drown out the loneliness. Fred and George, finding her crying one day, decide to take her under their wing. After pulling a prank with them, Hermione forges a friendship with the Weasley twins. Starting with Prisoner of Azkaban and ending with the Deathly Hallows, a take on what it would look like if Hermione did end up with Fred.
Disclaimer: I do not own the characters or the plot. They belong to J.K. Rowling, author of Harry Potter