Makayla and Alma, best friends, practically family. They're were-creatures, Makayla is a werwolf, but she can shape shift into an actual black wolf, she's one of her kind. Alma is a were-fox, but she can shape shift into an actual red fox, she's one of a kind.
When their pack is killed by hunters, they encounter the Winchesters, Sam and Dean, who can't figure out if they should kill them or keep them alive. That's when Makayla and Alma's lives change, but they haven't figured out if it's for better or worse. Then the biggest change in life happens for the two girls, they fall in love with hunters.