Unhappiness, pain or suffering, or a situation that makes a person suffer.
1) Her daughter's illness has been a source a great tribulation.
2) The play is about the tribulations of a family of immigrants in New York.
Middle English tribulacion, from Anglo-French, from Lation tribulation, tribulatio which means 'to press' or 'oppress'.
affliction, agony, anguish, hurt, misery, torment, pain rack
calm, comfort, happiness, peace